Mapping of nervous system diseases via MicroRNAs by Christian Barbato, Francesca Ruberti PDF

By Christian Barbato, Francesca Ruberti

ISBN-10: 148226353X

ISBN-13: 9781482263534

In fresh years, figuring out of microRNA (miRNA) biogenesis, the molecular mechanisms in which miRNAs keep watch over gene expression, and the practical roles of miRNAs has elevated. Mapping of worried procedure ailments through MicroRNAs presents an up to date assessment at the functionality of miRNA in neurological ailments in addition to developments in know-how for healing modulation of miRNA activity.

MicroRNAs are small RNA molecules that keep an eye on gene expression post-transcriptionally. A growing to be physique of facts means that miRNAs are dysregulated in different neurological issues. as well as reviewing common ideas and novel insights on mind functionality with regards to miRNA, this booklet additionally examines the position of miRNA in:

  • Neurological diseases
  • Neurodegenerative diseases
  • Neuropsychiatric diseases
  • Neurodevelopmental diseases

The e-book additionally discusses the importance of miRNAs as diagnostic instruments, biomarkers, brokers, and pursuits within the detection and therapy of neurological ailments. every one bankruptcy comprises fabric concerning destiny diagnostic and healing advances.

Molecular and mobile neurobiological stories of miRNA-mediated gene silencing within the worried approach have opened new frontiers for the advance of recent diagnostic exams and genetic remedies for neurological illnesses. protecting the total diversity of proper innovations and giving a glance into current and destiny probabilities, Mapping of apprehensive process ailments through MicroRNAs is an important state of the art reference for neurologists, neuropathologists, and researchers and practitioners in a variety of similar fields.

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Heritability is ~39%–42% for unipolar depression (Flint and Kendler, 2014), 70%–80% for BPAD (Craddock and Sklar, 2013), and 30%–67% for anxiety disorders (Domschke and Deckert, 2012). Candidate genes for unipolar depression include BDNF, 5HTT, FKBP5, TPH2, and HTRA2 (Flint and Kendler, 2014). , 2012). There has been little progress in identifying candidate genes for specific anxiety disorders. Therefore, although the evidence-base points to considerable genetic influence on both mood and anxiety disorders, current thinking is that genetic influences arise from many genes with small effect.

Wayman GA, Davare M, Ando H, Fortin D, Varlamova O et al. 2008. An activity-regulated microRNA controls dendritic plasticity by down-regulating p250GAP. Proc Natl Acad Sci USA 105:9093–8. Wu J, Xie X. 2006. Comparative sequence analysis reveals an intricate network among REST, CREB and miRNA in mediating neuronal gene expression. Genome Biol 7:R85. Yoo AS, Staahl BT, Chen L, Crabtree GR. 2009. MicroRNA-mediated switching of chromatin-remodelling complexes in neural development. Nature 460:642–6.

2013). A positive association was found between miR-212 levels in the dentate gyrus and in whole blood indicating that miRNA changes in the periphery can reflect changes occurring in the brain following antidepressant treatment. Subsequently O’Connor et al. (2013) investigated changes in miRNA levels in the MD model of depression following treatment with ECS, ketamine, or fluoxetine. , but the differences in time points used 36 Mapping of Nervous System Diseases via MicroRNAs post-ECS in these studies might account for this.

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Mapping of nervous system diseases via MicroRNAs by Christian Barbato, Francesca Ruberti


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