I Barry Holland,Susan P. C. Cole,Karl Kuchler, et's ABC Proteins. From Bacteria to Man PDF

By I Barry Holland,Susan P. C. Cole,Karl Kuchler, et al.Elsevier|Elsevier Science||Academic PressAdult NonfictionScienceLanguage(s): EnglishOn sale date: 13.10.2011Street date: 07.01.2003

ISBN-10: 0080481876

ISBN-13: 9780080481876

ABC Proteins is an in-depth, updated research of all that's recognized concerning the topic to this point. It discusses and compares evolution, biology and mechanism of motion of all recognized ABC proteins, together with the 1st structural reviews in addition to medical implications. it will likely be invaluable to somebody attempting to remain abreast of the most recent findings. This publication is certain to turn into a vintage and should frequently be updated.

Key Features

  • Phylogeny and Evoloution of ABC Transporters
  • Fundamental facets of the Mechanism of motion of ABC Transporters
  • Prokaryote ABC Transporters
  • Non-Mammalian Transporters
  • Multidrug Transporters
  • ABC Transporters, Physiological Roles and Human Disease
  • Full colour all through
  • Show description

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    Additional resources for ABC Proteins. From Bacteria to Man

    Sample text

    De, Institut für Physiologische Chemie, Klinikum, Universität Marburg, Karl-von-Frisch-Str. ca, Centre de Recherche en Infectiologie and Département de Biologie médicale, Université Laval, 2705, boul. de, Institut für Zytobiologie und Zytopathologie der Philipps-Universität, Marburg, Robert-Koch-Str. 5, 35033 Marburg, Germany Kenneth J. uk, University Laboratory of Physiology, University of Oxford, Parks Road, Oxford OX1 3PT, UK Anne T. ca, Centre de Recherche en Infectiologie and Département de Biologie médicale, Université Laval, 2705, boul.

    Since ATP is found principally in the cytosol, we define import as the inwardly directed transport of a molecule into the cytosol. By contrast, export is the translocation of a molecule out of the cytosol, even if its final location is an intracellular organelle. ABC systems of the three types can be distinguished on the basis of the design of their component parts. All the transporters are composed of four structural domains: two very hydrophobic membrane-spanning or integral membrane domains (IMs) and two hydrophilic cytoplasmic domains containing the ABC, peripherally associated with IM on the cytosolic side of the membrane.

    1990;346:362–365. F. The ABC (ATP-binding cassette) transporters of Escherichia coli. Mol. Microbiol. 1998;28:5–13. C. The E. coli BtuCD structure: a framework for ABC transporter architecture and mechanism. Science. 2002;296:1091–1098. , Callaghan R. The vinblastine binding site adopts high and low affinity conformations during the transport cycle of P-glycoprotein. Biochemistry. 2001;40:15733–15742. F. Energy coupling to periplasmic binding protein-dependent transport systems: ATP hydrolysis during transport.

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    ABC Proteins. From Bacteria to Man by I Barry Holland,Susan P. C. Cole,Karl Kuchler, et al.Elsevier|Elsevier Science||Academic PressAdult NonfictionScienceLanguage(s): EnglishOn sale date: 13.10.2011Street date: 07.01.2003


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